Vaginal Probiotic Suppositories

Evvy’s Vaginal Probiotic Suppositories work by delivering probiotics directly where they’re needed most — the vagina. By bypassing the digestive system, they place beneficial Lactobacillus bacteria right into the vaginal environment, where they can get to work restoring balance. These good bacteria help re-establish an acidic pH, produce natural antimicrobial compounds, and prevent harmful bacteria and yeast from overgrowing. 

Our Vaginal Probiotic Suppositories also go a step further by combining protective Lactobacillus strains with lactoferrin, a powerful antimicrobial protein that helps control unwanted bacteria and yeast. Together, these ingredients support a balanced vaginal microbiome, reduce symptoms like abnormal odor or discharge, and help maintain long-term comfort. 

For best results, insert one vaginal suppository 2–3 nights per week, or follow the instructions provided by your healthcare provider.

Evvy’s Vaginal Probiotic Suppositories are designed to go beyond standard probiotics by delivering targeted support directly to the vagina. The formula combines a proprietary multi-strain probiotic blend (including Lactobacillus crispatus, Lactobacillus rhamnosus GR-1, and Lactobacillus reuteri RC-14) to help maintain a low pH, produce natural antimicrobials, and support a stable, resilient microbiome. 

These are paired with lactoferrin, a natural protein that inhibits harmful bacteria and yeast, vitamin E to soothe and hydrate tissues, and a moisturizing, pH-balanced base that creates an environment where protective bacteria can thrive. 

Together, these ingredients restore balance, strengthen defenses, and support lasting comfort.

With clean hands, gently insert one suppository deep into the vagina, similar to how you would insert a tampon without an applicator. The suppository will dissolve on its own, releasing protective probiotics and supportive ingredients directly where they’re needed most. For ongoing support, use one suppository 2–3 nights per week, or follow the specific guidance provided by your healthcare provider. Many people also find it helpful to use a panty liner after insertion, as some natural residue may appear while it dissolves.

Ideal for monthly maintenance or to rebalance your microbiome after sex, your period, antibiotics, or other disruptions — backed by data on 20,000+ Evvy Rx users.

Note: Refrigeration required to maintain firmness for insertion.

Most of the time, they take about 10-15 minutes to dissolve, but sometimes it can take up to 30 minutes. Once the suppository melts away, the ingredients get absorbed into the vaginal lining.  

Yes, when made with the right ingredients and under proper clinical standards, vaginal probiotic suppositories are safe for most people. At Evvy, we’re committed to providing the most effective care possible, which is why our Vaginal Probiotic Suppositories are compounded in a 503a NABP-accredited pharmacy for prescription-grade quality you won’t find over the counter. 

They’re made with clean, non-toxic ingredients and contain zero fragrance, essential oils, or irritating additives. Our formula was developed by the same researchers and dataset behind Evvy’s world-leading vaginal microbiome test, trusted by over 75,000 people for personalized vaginal health. This means every ingredient is backed by science and chosen with safety and efficacy in mind.

That said, your specific prescription will always be determined by an Evvy-affiliated provider to ensure care is safe, compliant, and personalized for you. Please note that we cannot prescribe this treatment via telehealth if you are pregnant, breastfeeding, under 18, or over 80.

Evvy Vaginal Probiotic Suppositories aren’t recommended if you’re pregnant, breastfeeding, or have a coconut allergy. Our Moisturizing Base is coconut oil free but the formulation does contain palmitic acid. Palmitic acid may come from palm or coconut sources and is not suitable for individuals with coconut allergies.

It’s also not vegan, since lactoferrin contains dairy, but you can request a vegan, dairy-free version without lactoferrin in your Rx Intake Form. 

For the most effective results, we recommend taking an Evvy Vaginal Health Test first. Your prescription will be personalized by an Evvy-affiliated provider based on your test results or symptoms. 

Store Evvy Vaginal Probiotic Suppositories in the fridge to keep them firm enough to insert. To use, gently insert one suppository 2–3 nights per week, or follow the schedule recommended by your healthcare provider.

For targeted vaginal support, Evvy’s Vaginal Probiotic Suppositories deliver protective Lactobacillus bacteria directly to the vagina to restore pH balance and reduce symptoms like odor or discharge. Enhanced with lactoferrin and clinically-studied strains like Lactobacillus crispatus, these suppositories provide focused relief where it matters most. They’re perfect for monthly maintenance or to rebalance your microbiome after sex, your period, antibiotics, or other disruptions. 

If you’re looking for full-body microbiome support, including gut, urinary, and vaginal health, Evvy Women’s Complete Probiotic is a great choice. Its clinically-studied probiotics, postbiotics, targeted vitamins, and patented delayed-release technology help promote healthy bacteria, support yeast balance, and reduce bloating, all with just one daily capsule. 

Yes! Oral probiotics, like Evvy Women’s Complete Probiotic, support your gut, urinary, and vaginal health from the inside, while Evvy Vaginal Probiotic Suppositories provide targeted support directly to the vagina. Using both together can give you comprehensive, full-body microbiome support, helping maintain balance and comfort more effectively than either option alone.