Estradiol Vaginal Cream

Localized, low-dose hormonal relief for symptoms like dryness and painful sex. Unlike typical options, our formula is free from parabens and sulfates for clean, gentle care.

Relieves dryness
Free from parabens and sulfates
Supports a healthy vaginal microbiome

Our Estradiol Vaginal Cream offers localized, low-dose hormonal relief for menopausal symptoms like dryness, painful sex, and UTIs. Unlike typical options, Evvy’s formula is free from parabens and sulfates for clean, gentle care.The small amount of estrogen in this cream also nourishes your protective bacteria to balance vaginal pH and rejuvenate vaginal tissue.

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30 grams · $1.15 per dose

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$62.10

30 gram tube every 6 months
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Max 6 units

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HSA/FSA Eligible

This is a prescription product. A licensed, Evvy-affiliated provider will determine your prescription at their sole discretion.

Ingredients

USP-grade Estradiol 0.01% (each gram of Estradiol Vaginal Cream USP, 0.01% contains 0.1 mg estradiol)

How to Use

Insert 0.5 g of cream intravaginally daily for 2 weeks, then reduce to 2-3 times weekly to maintain results; This is the suggested dose, however it may be adjusted according to your symptoms.

You may use it daily for up to 4 weeks until natural moisture is restored and you feel an improvement.

Quality

For our Rx Symptom Relief Products, we use only prescription-grade, non-toxic ingredients that are free from harmful additives.

Non-Toxic
No PFAs
No Parabens
No BPAs
No Phthalates
No GMOs
No Sulfites
No Artificial Colors/Fragrances/Dyes

Please note that this Rx Product is designed to support vaginal health, but is not prescribed to treat an underlying condition. Evvy’s Vaginal Microbiome Test and Treatment Programs can diagnose and treat the root causes of symptoms.

This is a compounded medication, formulated in a 503a NABP-accredited pharmacy. Compounded products are not approved by the FDA.

Eligibility

Your specific prescriptions will be determined at the sole discretion of an Evvy-affiliated provider. To ensure safe, compliant, and personalized care, we cannot prescribe this treatment via telehealth for patients who are:

Pregnant
Breastfeeding
Younger than 18 or older than 80 years old

Currently, Estradiol Vaginal Cream is only available if you are menopausal or diagnosed perimenopausal, do not have a history of blood clots, do not have HIV, and do not have ovarian, endometrial, cervical, or breast cancer.

This treatment is not yet available in Canada or the following US states: Arkansas, Delaware, Kansas, Kentucky, Mississippi, New Mexico, Puerto Rico, Rhode Island, South Carolina, Vermont, US Virgin Islands, Washington DC, West Virginia, Armed Forces Europe / Pacific

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developed by researchers + OB/GYNs

Uniquely formulated for women

science-backed ingredients

No harsh additives

Why Estradiol Vaginal Cream

Support a Balanced Vaginal Microbiome

Relieves dryness, painful sex, and burning

Free from parabens and sulfates, unlike typical options

Restores elasticity

Why our formulation

Paraben-Free Menopause Symptom Relief

Estradiol (Vaginal Estrogen)

Relieves dryness, painful sex, & more.

Estradiol is the active form of estrogen that’s bioidentical to what the body naturally produces.

When estrogen levels drop during menopause, vaginal tissue can thin, pH can rise, and beneficial bacteria can decline — leading to dryness, pain, and recurrent irritation. We use USP-grade estradiol to help bring your vaginal microbiome back into balance and restore moisture, elasticity, and comfort.

Backed by science & designed by OB-GYNs

Backed by science, and clinically proven

as many post-menopausal women had an improvement in vaginal symptoms compared to those who took placebo. (Lethaby 2016)

75%

of women taking vaginal estrogen reported an improvement in pain with sex at 12 weeks. (Goetsch 2023)

80%

of patients using vaginal estrogen improved vaginal pH and levels of protective Lactobacillus bacteria. (Galhardo et al 2006)

How It Works

Step 1

Order your Rx from Evvy

All Evvy prescription (Rx) products are custom compounded at a 503a NABP-accredited pharmacy, ensuring high-quality, clean ingredients.

Step 2

Complete your intake form

A licensed, Evvy-affiliated provider will review your order and intake form within 24 hours. We’ll reach out to you over email if there are any questions.

Step 3

Rx shipped to your door

If prescribed, your prescriptions will be shipped straight to you and typically arrive within 3-6 business days.

Step 4

Test with Evvy for root cause

Evvy’s products are designed to relieve symptoms, not treat underlying conditions. Taking an Evvy test gives you a complete picture of your vaginal health and empowers you to address root causes, not just symptoms.

From the community

Providers and patients choose Evvy

"Vaginal estrogen is one of the most effective and underused options for restoring comfort after menopause. A small, localized dose of estradiol doesn’t just relieve dryness and pain — it actually helps restore the protective Lactobacillus bacteria that keep the vaginal microbiome healthy and balanced."

Dr. Kate McLean

Chief Medical Officer, Evvy

"As a very active and young 69 year old I really appreciate the effectiveness of the vaginal estrogen cream. The cream relieves the vaginal dryness and urinary urgency I started to experience. It works well for me."

Susan

Verified Evvy User

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FAQ's for Estradiol Vaginal Cream

For more, visit our Help Center

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Are these treatments prescribed by a provider?

Yes, all treatments are prescribed by a provider and compounded at a 503a NABP-accredited pharmacy. If there is a mismatch between what you request and what the provider recommends, we will confirm with you before shipping.

Do these treatments require a live video or phone call with a provider?

Nope! To ensure that our customers are able to get care in a convenient and affordable way, Evvy-affiliated providers offer asynchronous consultations. This means your provider will review your results and intake without requiring a phone or video call. If your provider has any questions, we will reach out to you over email before prescribing. Research shows that there's no significant difference between async and in-person/live consultations in terms of treatment outcomes — but it's something we're looking into offering in the future for those who want it.

What's the difference between the Evvy Complete Treatment Program and Evvy's individual Rx products?

The Evvy Complete Treatment Program is only available after taking an Evvy test, and offers a fully personalized, multi-step care plan based on your unique vaginal microbiome results. It combines targeted medication, symptom relief products, and probiotics into one coordinated approach, complete with 1:1 coaching and progress tracking. This integrated program optimizes both immediate relief and long-term balance, unlike standalone Rx treatments that typically target a single symptom.

For those looking to soothe discomfort while waiting to test, Evvy’s prescription symptom relief products are a great option. These treatments offer effective relief for common symptoms like itching and dryness, making them ideal for anyone seeking comfort before diving into a more comprehensive care plan.

What is the difference between Evvy's treatments from what I can get from my doctor or what I can get over the counter?

Evvy’s treatments are formulated based on years of research plus our unique R&D on the vaginal microbiome, with insights from over 7,000 individuals to determine what truly works for vaginal health. Our treatments are prescription-grade and carefully compounded with the highest quality, non-toxic ingredients to ensure effective, targeted relief. Unlike standard treatments, Evvy’s formulations also consider the form factor and delivery method, optimizing each treatment to work safely and effectively with your body. Our platform offers a fully personalized experience, from expert-reviewed treatment recommendations to ongoing support, so you’re not just addressing symptoms—you’re actively supporting your long-term vaginal health.

The Evvy platform has helped 75,000+ people take control of their vaginal health

I am so thankful for Evvy’s treatment plan and guidance... Evvy’s approach felt much more comprehensive and I finally have relief after years of struggling.

Graciela

Verified Customer

Evvy actually saved my life. I couldn't be more happy with the detailed test results, relevant and cutting-edge information, and immense support.

Pia

Verified Customer

The level of detail in test results is unlike anything I could ever access through my doctor’s office... and [Evvy] dramatically changed my health.

Verified Customer

For the first time since developing symptoms, I felt heard, understood, and cared for. I could cry from happiness!

Hannah

Verified Customer