Estradiol Vaginal Cream

Evvy’s Estradiol Vaginal Cream is designed to bring lasting relief from the most common vaginal symptoms of menopause, like dryness, burning, irritation, and painful sex. It delivers a gentle, localized dose of estrogen directly where your body needs it most to restore comfort, hydration, and microbiome balance.

A lot of vaginal estrogen creams out there contain unnecessary additives like parabens and sulfates, which can disrupt your vaginal microbiome and cause irritation. Evvy’s formula is free from parabens and sulfates and compounded in a 503A NABP-accredited pharmacy, so you know it meets the highest prescription-grade standards. It was developed by the same researchers behind Evvy’s Vaginal Health Test, which over 75,000 women trust. Evvy’s Estradiol Vaginal Cream is thoughtfully created with your vaginal ecosystem in mind, ensuring comfort and promoting long-term microbiome health.

Yes. Low-dose vaginal estrogen is considered one of the safest and most effective options for relieving postmenopausal vaginal symptoms, even with long-term use. Because it’s applied locally, only a small amount enters the bloodstream, making it a low-risk option for most people. As always, we recommend checking in with your healthcare provider before starting any new prescription if you have a history of hormone-sensitive conditions.

Evvy’s Estradiol Vaginal Cream can help with some of the most common genitourinary symptoms of menopause, including:

• Vaginal dryness and irritation
• Painful sex (dyspareunia)
• Vaginal burning or itching
• Recurrent urinary discomfort or infections
• Loss of elasticity or thinning of the vaginal tissue

When estrogen levels drop during menopause, vaginal tissue can become thinner, drier, and more fragile, and the microbiome often shifts away from its protective balance. Low-dose estradiol replenishes estrogen directly where it’s needed, helping to rebuild and hydrate the vaginal lining, restore elasticity and natural lubrication, and support Lactobacillus growth to balance vaginal pH.

You can get Evvy’s Estradiol Vaginal Cream directly through evvy.com (no in-person appointment required). Start with a quick online consultation to see if it’s right for you, and if prescribed, our partner pharmacy will compound your personalized formula and ship it straight to your door.

Absolutely. Evvy’s Estradiol Vaginal Cream was made for menopausal and postmenopausal women who want to restore comfort without compromising on safe, science-backed care. It delivers localized relief, meaning it works directly at the vaginal tissue and doesn’t have the same systemic effects as oral or patch-based hormone therapies.

Most people start noticing improvements in moisture, comfort, and flexibility within 2–4 weeks of consistent use. For best results, use 0.5 g daily for the first two weeks, then reduce to 2–3 times per week to maintain results. You can continue daily use for up to four weeks until natural moisture is restored. Your clinician may adjust your plan based on how your body responds.

Evvy’s Estradiol Vaginal Cream is gentle and well-tolerated. There aren’t any known major interactions, but we always recommend avoiding other vaginal products (like antifungal creams or douches) at the same time unless directed by your clinician. If you’re using other prescriptions or supplements, let your healthcare provider know. They’ll help ensure your care plan stays balanced and effective.

Our Estradiol Vaginal Cream is made with a hypoallergenic base and is free from major allergens.

Yes, it is paraben-free

Vaginal estrogen is considered very safe for most people because it works locally, with very little hormone absorbed into the rest of the body. In November 2025, the FDA announced it is removing the “black box” warning from estrogen-containing products, recognizing that the old warnings overstated risks like cancer and heart disease - especially for low-dose vaginal estrogen. Serious side effects are extremely rare, but you should still talk to your healthcare provider if you have a history of hormone-sensitive cancer or blood clots.

Vaginal estrogen works right where it’s needed—on the vaginal tissue—to relieve dryness, irritation, and pain, with very little hormone entering the bloodstream. Systemic hormone therapy, like pills or patches, affects the whole body and is typically used to treat broader menopause symptoms such as hot flashes or mood changes.

Most people in perimenopause or menopause benefit from low-dose vaginal estrogen. As estrogen levels drop, the vaginal tissue becomes thinner and less hospitable to protective Lactobacillus bacteria. Estrogen helps restore the tissue environment and supports a healthy, balanced microbiome.

While vaginal estrogen can sometimes be helpful for postpartum changes or other causes of vaginal dryness and irritation, at this time Evvy is only able to prescribe vaginal estrogen for individuals who are perimenopausal or menopausal.

If you’re experiencing symptoms outside of those life stages, it’s definitely worth discussing with your in-person provider, who can evaluate whether estrogen or another option may be appropriate for you.