If you’ve ever dealt with bacterial vaginosis (BV), you know how uncomfortable it can be. From unusual vaginal discharge to a fishy smell, bacterial vaginosis is a really common vaginal infection, affecting millions of women every year. It’s also frustratingly difficult to get rid of once and for all. If you’ve tried the usual solutions, you may be wondering if other antibiotics, such as amoxicillin, may do the trick.
The short answer: not really. While amoxicillin is a powerful antibiotic that fights many types of bacterial infections, bacterial vaginosis is a little more complicated. BV happens when the natural balance of bacteria in the vagina shifts, leading to a bacterial overgrowth.
Keep reading to understand why amoxicillin usually isn’t the most effective treatment, plus how to treat and prevent bacterial vaginosis effectively.
What is amoxicillin?
You’ve probably heard of amoxicillin before, especially if you’ve ever had strep throat or an ear infection. Amoxicillin is a widely used antibiotic in the penicillin family. It's typically prescribed to treat bacterial infections such as strep throat or ear infections, among other infections — it’s known as a broad-spectrum antibiotic for that reason.
Can amoxicillin treat BV?
While amoxicillin is a powerful antibiotic used to treat many bacterial infections, it’s not the best option to treat bacterial vaginosis. Instead, doctors usually recommend antibiotics like metronidazole or clindamycin, either taken orally or as a vaginal cream. These medications are specifically designed to target the anaerobic bacteria that cause bacterial vaginosis.
Antibiotics are most effective when they match the bacteria responsible for the infection. Amoxicillin can be effective against bacteria such as Streptococcus and Staphylococcus, which are often responsible for infections in the throat and ears,
On the other hand, bacterial vaginosis is a vaginal infection caused by an overgrowth of anaerobic bacteria like Gardnerella vaginalis, Prevotella, and Atopobium vaginae, all of which thrive in low-oxygen environments. Since amoxicillin isn’t effective against these specific bacteria, it’s not the best choice to treat bacterial vaginosis.
Taking an antibiotic like amoxicillin when it’s not appropriate can sometimes create more problems than it solves. It might not completely clear up the infection and could upset the balance of bacteria in your vagina, possibly leading to complications, recurrent infections, or antibiotic resistance. That’s why healthcare providers focus on antibiotics like metronidazole or clindamycin. These treatments have been shown to target and eliminate the specific bacteria linked to BV effectively.
Side effects of amoxicillin
If amoxicillin is prescribed for another infection, it’s good to be aware of potential side effects:
- Nausea
- Diarrhea
- Rash
- Yeast infections (due to disruption of normal bacterial flora)
- Allergic reactions (rare but serious).

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How to treat bacterial vaginosis
If you’re experiencing symptoms of BV, the most effective approach is to get a proper diagnosis and follow a targeted treatment plan. Most commonly, treatment options involve:
- Oral metronidazole
- Metronidazole vaginal gel
- Clindamycin vaginal cream.
It’s crucial to take the full course of your prescribed medication, even if your symptoms improve before you finish it. Stopping treatment early can allow the infection to return or get worse, making it harder to treat.
One helpful resource is Evvy’s Vaginal Health Test, which uses advanced microbiome analysis to identify the bacterial makeup of your vagina and pinpoint the cause of your symptoms. If your test finds high amounts of BV-causing bacteria, eligible users will have access to a personalized prescription treatment program developed by a provider.
Bacterial vaginosis prevention
Preventing bacterial vaginosis involves a mix of hygiene habits and lifestyle choices that support a healthy vaginal environment. Here are some effective strategies:
- Avoid douching: Douching disrupts the natural balance of bacteria in the vaginal microbiome, washing away both harmful and beneficial bacteria. This makes it easier for harmful bacteria to overgrow and cause bacterial vaginosis. The vagina is self-cleaning, so there’s no need for extra help!
- Use condoms and dental dams during sex: Unprotected sex (especially with multiple sex partners) is one of the biggest risk factors for bacterial vaginosis. Semen can alter the vaginal pH, making it more alkaline, which encourages the growth of bacteria responsible for bacterial vaginosis. Condoms help maintain your vaginal pH balance and reduce the risk of introducing new bacteria.
- Avoid heavily scented soaps and feminine hygiene products: These products can irritate the vaginal area and disrupt the microbiome, making it easier for harmful bacteria to take over. Stick with mild, fragrance-free options designed for sensitive skin.
- Monitor your vaginal health: Getting to know what’s normal for your body helps you catch changes early. Products like Evvy’s Vaginal Health Test test make it easier to track shifts in your vaginal health and take action before bacterial vaginosis has a chance to take hold.
FAQ
Is amoxicillin ok for BV?
While amoxicillin is a valuable antibiotic for many health conditions, it’s not the right choice for treating bacterial vaginosis. BV requires targeted treatment with specific antibiotics like metronidazole or clindamycin that are proven to work against the bacteria responsible. If you think you might have BV, consult with a healthcare provider or consider an at-home testing and treatment option like Evvy to get personalized care that actually works.
What antibiotics can clear up BV?
Healthcare providers typically prescribe antibiotics that target the specific anaerobic bacteria causing the infection. The most commonly recommended antibiotics for bacterial vaginosis include metronidazole, which can be taken orally or used as a vaginal gel, and clindamycin, which is available in cream form for vaginal use. Another option is tinidazole, an oral antibiotic similar to metronidazole, but with fewer side effects. These antibiotics are specifically chosen because they work against the anaerobic bacteria responsible for bacterial vaginosis, helping to restore the balance of bacteria in the vagina.
Can amoxicillin throw off your pH balance?
Amoxicillin, like other antibiotics, works by targeting and killing bacteria, but it’s only effective when taken for the right reason, such as for treating infections like strep throat. However, using amoxicillin when it's not needed, such as for treating bacterial vaginosis, can throw off the balance of bacteria in your body, including in your vagina. The vagina relies on a delicate pH balance to keep harmful bacteria in check, and taking antibiotics unnecessarily can disrupt that balance. This disruption may lead to side effects like yeast infections or even contribute to the recurrence of bacterial vaginosis, as it can affect the good bacteria that help maintain a healthy environment. So, while amoxicillin is effective for certain conditions, it's important to only use it when prescribed for the appropriate bacterial infection.