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Meet Your Microbiome

Every day, your vagina performs the equivalent of modern health miracles.

It can fight off infections, defend against cancers, and protect a pregnancy. And the quality of its defense is determined by the composition of your vaginal microbiome — a complex ecosystem of bacteria, fungi, viruses, and more.

How does my microbial defense actually work?
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Given that the vagina is the structural connection between the outside world and some of our most important reproductive organs, the local microbiome has evolved to serve as a critical layer of protection against pathogens entering our bodies.

While there is a variety of bacteria and fungi that can exist in the vagina, Lactobacillus are the local heroes. Lactobacilli ensure that the vaginal environment is inhospitable for potential pathogens in a variety of ways:

1) Producing lactic acid that helps keep the pH low and healthy (ideally between 3.8 and 4.5)
2) Taking up space on the vaginal wall, preventing other pathogens from being able to thrive
3) Producing bacteriocins, which further inhibit pathogens
4) Keeping inflammation down in the genital tract.

When this environment is in an optimal state, it can do amazing things. A balanced vaginal microbiome can lower your risk for:

  • STIs like chlamydia, gonorrhea, trich, herpes, HPV, and HIV
  • Pelvic Inflammatory Disease
  • Fertility complications like infertility and failed IVF
  • Pregnancy complications like miscarriage, preterm birth, neonatal problems, and preeclampsia
  • Gynecological cancers like ovarian cancer and cervical cancer
  • Cervicitis
  • Toxic Shock Syndrome
Are my frequent vaginal infections related to my microbiome?
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Yes! The viruses, fungi, and bacteria that cause vaginal infections are all part of your microbiome. When your microbiome is imbalanced, it creates opportunity for these bad microbes to thrive.

If you’re one of the ~30% of people with vaginas that will get BV this year, that means your vaginal microbiome has a wide variety of bacteria (called dysbiosis) instead of a Lactobacillus bacteria playing the main role in creating that all-important lactic acid environment.

On top of that, 84% of BV cases are asymptomatic, meaning that you might not even know if your vaginal microbiome is imbalanced — but you might still be at risk for infection or other complications.

Dysbiosis of the vaginal microbiome can catalyze other types of infections as well, such as aerobic vaginitis, yeast infections, cytolytic vaginosis (CV), UTIs, all of which can have frustrating (and confusingly similar) side effects, such as itchiness, abnormal discharge, and burning.

One important thing to note: research shows that dysbiosis is more prevalent in Black and Hispanic women, but there is a disappointing lack of research explaining why that is or how we can change it. More broadly, it’s incredibly frustrating that research on this topic has not been more highly prioritized in medicine overall, given the prevalence of vaginal dysbiosis and its impact on our quality of life.

…Go on…  

We know, we know — we could talk about this for hours. But let us point out a few more things —   the current methods for treating vaginal infections are as archaic as diagnosing them.

Antibiotics and antifungals are widely used treatments which have high rates of success in the short term. However, in the long term, they’re not as great of a solution as you might think.  

While antibiotics and antifungals kill off the bad bacteria, they also kill off the good ones, rendering the vagina defenseless and highly susceptible to reinfection. In fact, vaginal infections have some of the highest rates of reinfection, with 80% of BV patients having a reinfection within 3 months and 60-70% of patients taking long term yeast infection treatment having a recurrence within 6 months afterwards.

There have been almost no advancements to improve cure rates for vaginal infections for decades. There is a pressing need for better, more sustainable solutions — and demystifying the microbiome to patients, doctors, and researchers can drastically improve treatment options in this space.

If my vaginal microbiome is so powerful, why haven’t I heard of it?
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Microbiome research is a relatively new field, and lots of resources have been invested in understanding other human microbiomes like the one in your gut or on your skin. But when it comes to your vagina, the microbiome has been overlooked.

We wish the reason why wasn’t yet another gender gap… but that’s why we’re here! Evvy exists to use cutting-edge research techniques to elevate the vaginal microbiome to its rightful place in research and clinical care, all while providing you with critical insights into your health.

How can I check in on my own microbiome?
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Well — that’s the other reason why we exist.

Evvy’s first product willbe the only at-home test that leverages metagenomic sequencing, an advanced form of next-gen sequencing that analyzes the entire genome. This allows us to pick up on all bacteria present at an extremely specific level.

In addition, Evvy won't just return a table of numbers. Evvy results come with actionable recommendations and curated insights on how your vaginal microbiome is related to your holistic health — customized to you based on your specific microbes, symptoms, and experiences.

You’ve convinced me my microbiome is important...how can I take care of it?
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Here’s the thing about vaginas: they’re pretty great at taking care of themselves. They’re self-cleaning and normally self-protecting, as long as the vaginal microbiome is in balance.

However, many of the things we enjoy — sex and sugar, for example — are good at throwing off this balance.

Plus our bodies naturally change over time, and trying new birth control, medications, sexual partners, period products, and more can add chaos to this balancing act.

There are some all-around great things you can do to take care of your vaginal microbiome — and we’re pretty sure you’ve heard them before: Drink water, never douche, wear cotton underwear, pee after sex, cut down on sugar, change out of wet swimsuits as soon as you can, the list goes on.

But surprise! Not all vaginas are the same. What works for you might not work for your sister or your friend. So the best way to care for your unique microbiome is to first understand what your microbiome looks like (what bacteria are present) and whether or not it is optimally balanced (psst...that’s what we made the Evvy vaginal microbiome test for!)

And when you do intervene (try a new probiotic, change your diet, etc.),  Evvy will take the guesswork out of figuring out which solution is working for you. By retesting, you can see how changes you’re making in your diet, life, and supplements are impacting your vaginal microbiome’s defense.

We envision a world where everyone with a vagina is in control of their own health through personal data, accessible research, and empathetic care.
Scientific accuracy is important to us.
See what we're reading and citing here.

What is Bacterial Vaginosis (BV)? 

Everything you wanted to know about BV but were afraid to ask: what is it, what causes it, and how to get rid of it.

Maybe you’ve gotten a recent diagnosis from your doctor. Maybe you’re dealing with recurrent vaginal infections. Maybe you’re just curious about what’s up down there. Whatever you’re here to learn, Evvy’s got answers. 

Looking for something we didn’t cover here? Let us know at ask@evvy.com or with #AskEvvy on social. 

Oh, and let us say one more thing before we get into it: you’re not alone. We know too well that common types of vaginal infections like BV, yeast, UTIs and more can sometimes bring on feelings of frustration, fear, or even shame — but they shouldn’t. Taking care of your health is a normal part of being human — and we’re here to help. 

What is bacterial vaginosis (BV)? 

Bacterial vaginosis, or BV, is the diagnosis given when you have an overgrowth of bacteria in your vaginal microbiome — including some bacteria like gardnerella that may be harmful. (Need a refresher on the vaginal microbiome? We’ve got you.) 

This overgrowth in vaginal flora is in contrast to a healthy vaginal microbiome, which is dominated by Lactobacilli, a lactic-acid producing bacteria that resist pathogens. When the lactobacilli-dominance is disrupted, your vaginal pH can go up, allowing other types of bacteria to grow and cause an imbalance (sometimes referred to as dysbiosis) — which then causes a variety of symptoms. 

How is BV diagnosed? 

BV is typically diagnosed two ways. The first is symptomatically, based on something called the Amsel criteria. An Amsel criteria diagnosis is when you have 3 of the 4 following symptoms: white discharge, clue cells, a pH over 4.5, and a fishy odor. 

The more specific way to diagnose BV is with a Nugent score. Using the Nugent score, a vaginal smear is examined under a microscope for three bacteria morphotypes: Lactobacillus, Gardnerella, and curved gram rods.  A score is then created based on how many of each type have been counted, essentially looking for low, intermediate, or high diversity of bacteria in the sample. A score under 4 is diagnosed as healthy, 4-7 is intermediate, and 7-10 is considered high diversity, aka, BV. 

You may have noticed that “high diversity” isn’t a very specific diagnosis — and you’re right. Unfortunately, current diagnostic measures don’t tell you much about what other bacteria are present or any other relevant information about how they’re interacting in your vaginal microbiome. 

(A small aside — this is why we’re creating an at-home vaginal microbiome test, so you can understand all the bacteria present in your microbiome and why it matters, including what symptoms it may be related to. Though it’s not a diagnostic test, and shouldn’t replace the advice of your doctor, it can help you uncover what strains are present and in what capacity.)

Bacteria that is adhered to vaginal epithelial cells, known as clue cells. The presence of these clue cells is one of the signs that the patient has bacterial vaginosis. CDC/ M. Rein

What are the symptoms of bacterial vaginosis?

The most common complaints of folks with BV are: 

  • A fishy odor
  • White or gray vaginal discharge

Pain, discomfort, or itchiness, both in general or specifically with sex or peeing, may also occur. However, up to 84% of people with BV (read: an imbalanced vaginal microbiome) may not experience anything at all. 

How common is BV? 

If you’re dealing with BV, you’re far from alone.

According to the Center for Disease Control (CDC), BV is actually the most common vaginal condition in women ages 15-44.

In fact, almost 30% of people with vaginas get BV each year, and that number jumps to 50% for people of reproductive age (those in between puberty and menopause).

What causes BV?

Here’s a frustrating tidbit from the CDC: “Researchers do not know the cause of BV or how some women get it.” 

If you’re shocked that this is the best available answer for a condition that affects one in three women, you’re not alone. This is why Evvy exists! The vaginal microbiome and BV are massively understudied, and it’s time women and people with vaginas got the research and care they deserve. 

What treatments are available for BV? 

BV is often treated with antibiotics prescribed by a doctor. That said, antibiotics often wipe out all bacteria in a microbiome — including the protective strains — so talk to your doctor about adding a probiotic to your treatment plan. 

We hope that further research into the vaginal microbiome can create an opportunity for more precise and effective treatments in the future. 

Can you get BV from having sex? 

BV is not a sexually-transmitted infection (STI) and you can develop BV without ever having sex. 

Because BV is broadly defined as an imbalance in your vaginal microbiome, you can’t “get” BV from having sex with someone. That said, sex itself (or really putting anything in or near your vagina) can introduce new bacteria and/or change the vaginal pH, allowing “bad” bacteria an opportunity to overgrow and cause BV.  

Semen, saliva, or another vaginal microbiome can all disrupt your vaginal flora. This means that having unprotected sex, sex with a new partner, or sex with someone else with a vagina can increase your odds of developing BV — but read on to discover a few steps you can take to help prevent BV. 

How can I stop BV from coming back again? 

One way to help prevent a BV recurrence is to take a probiotic with helpful strains of vaginal bacteria regularly. This ensures that protective bacteria is always being introduced to strengthen your natural defense against pathogens — even if you’re taking antibiotics or using boric acid.

There are other every day behaviors you can do to help, and you’ve probably heard of some of them: 

  • Avoid douching and feminine hygiene products, which can imbalance your microbiome 
  • Wipe front to back
  • Change your period products within the proper time frame
  • Stick to underwear that is loose fitting, lightweight, breathable, and made from a natural fabric, and change it often
  • Wash sex toys often 
  • Reconsider smoking and diet habits (smoking and unhealthy fats are linked to an increased risk of BV) 
  • Incorporate meditation, yoga or exercise into your daily routine (the stress hormone cortisol can disrupt your vaginal flora!) 

What about recurrent BV? 

Recurrent bacterial vaginosis is unfortunately also common. Some studies show recurrence rates as high as 80%, 3 months after “effective treatment.”  Doesn’t sound so effective to us! 

Essentially, antibiotics are effective at killing off the “bad” bacteria, but they kill off the good bacteria, too. And without that good bacteria, the vagina’s natural defense is broken down, which is why women often feel better in the short term but recur shortly after.

How is boric acid used to treat BV? 

Over time, “bad” bacteria can build up a biofilm that makes it hard to get rid of. Boric acid breaks down this biofilm. 

However, treating BV is all about rebalancing your vaginal microbiome. This means that a key part of any solution is not just getting rid of the bad bacteria, but re-introducing healthy bacteria that naturally produce lactic acid to break down further biofilms and resist pathogens.

We should note: don’t start taking boric acid without consulting your doctor! Because it’s only part of the solution, it is important that you incorporate it into a doctor-approved treatment plan. And to ensure that the good bacteria can regrow, ask your doctor about taking a probiotic. 

What are the risks associated with BV? 

The bacteria present in the vagina influence the risk of a variety of other health issues. Untreated BV is associated with the following conditions, among others:

  • STIs: chlamydia, gonorrhea, trich, herpes, HPV, HIV 
  • Pelvic Inflammatory Disease
  • Fertility issues: infertility, failed IVF
  • Pregnancy issues: miscarriage, preterm birth, neonatal problems preeclampsia 
  • Gynecological cancers: Ovarian, Cervical
  • Cervicitis
  • Toxic Shock Syndrome 

What’s the difference between BV and a yeast infection? 

BV is not the same thing as having a yeast infection (also known as thrush), which is caused by candida (yeast). The main underlying difference is that yeast infections are caused by an overgrowth of candida, while BV is caused by an overgrowth of a variety of bacteria like gardnerella. 

Though the symptoms in these two vaginal infections may overlap, yeast infections are typically characterized by a specific type of vaginal discharge (often compared to cottage cheese) and itchiness, while BV is mostly associated with a fishy odor and thin white or grey discharge.

Are hormones related to BV? 

Hormones play a role in the composition of  the vaginal microbiome. Estrogen is an important variable in the health of your lactobacilli, the bacteria that create a lactic acid dominant environment in the vagina. Anything that changes estrogen levels can introduce risk of imbalancing the vaginal microbiome.

This means that there are times when it’s important to pay extra attention to your vaginal microbiome: starting your period, becoming pregnant, going through menopause, and going on or changing hormonal birth control. 

Can men get BV?

Only people with vaginas can develop BV, because by definition it is an imbalance in the vaginal microbiome. The penis has its own microbiome — but we’ll leave that for another day! 

Looking for something we didn’t cover here? Let us know at ask@evvy.com or with #AskEvvy on social.

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