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A woman using hyaluronic acid for skincare which can also be used for vaginal dryness.

How to Use Hyaluronic Acid for Vaginal Dryness

Learn how to choose the best hyaluronic acid products for vaginal dryness and follow step‑by‑step instructions on how to use them safely and effectively.

Last updated on Aug 01, 2025

Words by Olivia Cassano

Scientifically edited by Dr. Krystal Thomas-White, PhD

Medically reviewed by Dr. Sameena Rahman, MD

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You may have heard of the benefits of using hyaluronic acid in your skincare, but did you know you can also use hyaluronic acid for vaginal dryness? Not only can it keep the skin on your face plump and hydrated, but it can also do wonders for vaginal tissues.

Vaginal dryness can affect women at any age, but it’s most common in perimenopause and menopause. As you approach menopause, your body starts producing less and less estrogen. Estrogen is vital for vaginal health because it keeps the vaginal mucosa thick, elastic, and lubricated. 

Reduced estrogen levels can cause many uncomfortable symptoms, including vaginal atrophy, burning, irritation, and pain during sex, collectively called genitourinary syndrome in menopause (GSM). Research shows that around 65-84% of women going through menopause experience GSM. Women can experience estrogen deficiency at other points in their lives as well, for example, when breastfeeding or undergoing cancer therapy.

So, how can hyaluronic acid help? Keep reading to learn more. 

What is hyaluronic acid? 

Hyaluronic acid is a natural substance produced by the body. It’s found in your joints, eyes, and, more importantly, skin. It’s gooey and slippery and acts like a natural lubricant. It’s also a humectant, which means it binds to water to help your skin retain moisture — that’s why it’s so common in hydrating skincare products. 

When applied internally to the vagina, hyaluronic acid works by sticking to the vaginal epithelial cells and retaining water, which both hydrates and protects the vaginal epithelial cells. 

Vaginal dryness treatment with hyaluronic acid and more

There are several effective ways to treat vaginal dryness, both hormonal and non-hormonal. Two of the most commonly used treatments are vaginal estrogen and non-hormonal treatments like vaginal moisturizers, such as those containing hyaluronic acid.

While both vaginal estrogen and moisturizers relieve dryness, they work in different ways. Vaginal estrogen delivers a small, localized dose of estrogen directly to the vaginal tissues, helping rebuild moisture and elasticity over time. In contrast, vaginal moisturizers — often made with hyaluronic acid — work by hydrating and soothing the vaginal lining, reducing friction and inflammation. These moisturizers are typically used a few times a week and can provide long-lasting relief, even when you're not having sex.

It’s also helpful to understand that vaginal moisturizers are not the same as lubricants. Moisturizers offer ongoing hydration, while lubricants are used just before or during sex to make things more comfortable in the moment. That said, lube is great for everyone, not just people experiencing dryness. 

Treatment options for vaginal dryness may include:

  • Hormonal treatments, like vaginal estrogen or DHEA (prasterone) suppositories. 
  • Non-hormonal vaginal moisturizers, including those with hyaluronic acid. 
  • Water- or silicone-based lubricants for use during sexual activity. 
  • Non-hormonal prescription therapies, such as vaginal pH balancers or selective estrogen receptor modulators (SERMs). 
  • Vaginal moisturizers in gel or suppository form, designed for regular, non-sexual use. 
  • Lifestyle adjustments, including staying hydrated and avoiding scented soaps or products that may irritate the vaginal tissue. 

If you're unsure which option is best for you, talk to a healthcare provider, especially if you’re experiencing persistent dryness or discomfort.

Best hyaluronic acid products for vaginal dryness

When it comes to choosing a hyaluronic acid product for vaginal dryness, it’s important to look beyond the label. Many options on the market include additives like fragrances, thickeners, or preservatives that can irritate sensitive vaginal tissues and cause discomfort, especially in women with sensitive vaginal tissues or active inflammation.

Evvy’s Hyaluronic Acid Suppositories are designed with vaginal health in mind, free from unnecessary additives and made for comfort and safety. They’re:

  • pH-balanced and clinically tested for sensitive vaginal tissue
  • Formulated with 100 mg of prescription-grade hyaluronic acid per suppository to deeply hydrate and support healing
  • Made without PFAs, parabens, BPAs, phthalates, GMOs, sulfites, artificial colors, fragrances, or dyes
  • Safe for regular use, even during infections or microbiome imbalances. 

Whether you’re navigating perimenopause, recovering from an infection, or just managing daily dryness, Evvy’s Hyaluronic Acid Suppositories are a gentle, science-backed option for real relief, without the ingredients that might make things worse.

@evvybio 🔦Spotlight on Hyaluronic Suppositories for Vaginal Dryness and GSM! 🔗Learn more at the link in bio! #evvy #menopause #menopausedryness #femalehealth #menopausesupport #genitourinarysyndromeofmenopause ♬ original sound - Evvy Bio

How to use hyaluronic acid for vaginal dryness

Hyaluronic acid is an ingredient, not a product itself. You’ll find it in different formulations like vaginal gel, creams, or suppositories, and each product may have slightly different instructions for how and when to use it. That’s why it’s important to always read the label carefully and follow the directions specific to your chosen product.

In general, here’s how to use a hyaluronic acid-based vaginal moisturizer effectively:

  1. Choose a product specifically designed for vaginal use, containing hyaluronic acid, and free of fragrances or harsh additives.
  2. Wash your hands thoroughly before applying to maintain cleanliness and avoid introducing bacteria.
  3. Get into a comfortable position — lying on your back with knees bent or standing with one leg raised usually works well.
  4. Apply the gel or insert the suppository gently into the vagina using your finger or the provided applicator. Many people find it easiest to do this at night.
  5. Use it as directed, which may be every couple of days or more frequently, depending on the product and your provider’s guidance.

Be sure to follow the usage instructions on the packaging and consult your healthcare provider if you’re unsure. Regular, consistent use can help restore moisture and improve long-term vaginal comfort.

Should I use hyaluronic acid for vaginal dryness?

Research has shown that hyaluronic acid can be a great alternative to vaginal estrogen therapy. While admittedly there aren't a ton of studies on hyaluronic acid for vaginal dryness, recent evidence has found that applying it directly to the vagina can provide relief from dryness and irritation and performs well compared to low-dose vaginal estrogen. It’s also a great alternative for women who don’t want to take vaginal estrogen or hormones. 

According to a systematic review of nine studies, hyaluronic acid was found to be beneficial for postmenopausal women suffering from vaginal dryness, and all nine studies reported an improvement in vaginal dryness, itching, and sexual function. In addition, six studies showed an improvement in vaginal burning.

Hyaluronic acid has also been shown to improve vaginal dryness and pain during sex in women undergoing cancer treatment who can't take estrogen therapy. 

There hasn't been any research conducted yet on the effects of hyaluronic acid on the vaginal microbiome. So, we can't say for sure whether it can help replenish the levels of Lactobacilli in the vagina, which tend to decrease in menopause. Additionally, we can't be certain that hyaluronic acid can reduce the risk of urinary tract infections or vaginal infections, unlike estrogen. 

That said, vaginal moisturizers containing hyaluronic acid are specifically formulated to go inside the vagina, so it’s unlikely that they’ll alter your vaginal pH. 

Evvy's Hyaluronic Acid Suppositories have been designed to hydrate and restore the vaginal lining. They provide long-lasting relief from dryness, itching, and painful intimacy. 

We’ve put together a simple yet effective formulation that features prescription-grade hyaluronic acid, with no harsh irritants or additives. So they boost hydration and elasticity, without harming your vaginal microbiome or natural pH levels. 

Whether you're navigating hormonal changes like menopause or experiencing dryness from medications like certain birth controls, our suppositories are perfect for every stage of life. 

If you’re dealing with vaginal dryness, speak to your healthcare provider about the best course of action and whether hyaluronic acid might be a good solution for you.

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FAQ

Can you use hyaluronic acid on private parts?

Yes, hyaluronic acid can be used in the vaginal area. Hyaluronic acid is known for its hydrating and soothing properties, making it a common ingredient in vaginal moisturizers designed to alleviate dryness, especially for women experiencing menopause or hormonal changes. However, it's important to use products specifically formulated for vaginal use, like Evvy’s Hyaluronic Acid Suppositories and Soothing Vulva Cream. Avoid using general skincare products containing hyaluronic acid on your private parts, as they may include additional ingredients that could cause irritation. If you’re considering using a new product, it’s always a good idea to consult a healthcare provider for guidance.

What is the best way to moisturize your private area?

The best way to moisturize your private area is to use products specifically designed for intimate use. Opt for gentle, fragrance-free, and pH-balanced vaginal moisturizers or creams, such as Evvy’s Soothing Vulva Cream, which contains ingredients clinically studied for their efficacy, such as hyaluronic acid, vitamin E, and aloe vera. Before applying any moisturizer, clean your vulva with warm water and a mild, unscented soap. Pat the area dry gently with a clean towel, avoiding harsh rubbing. Apply the moisturizer externally to the vulva, not inside the vagina (unless the product is explicitly designed for internal use, such as Evvy’s Hyaluronic Acid Suppositories). You should avoid using lotions or creams intended for other parts of the body, as they may contain fragrances, preservatives, or other ingredients that can irritate sensitive skin. If you experience chronic dryness or discomfort, consult a healthcare provider, as they may recommend specific treatments like prescription estrogen creams or other tailored solutions.

Can I use hyaluronic acid as a lubricant?

That depends on what you mean by “lubricant”. Hyaluronic acid can be a safe and effective added ingredient in lubricants, particularly for those dealing with vaginal dryness. Its hydrating properties help retain moisture and enhance comfort during intercourse. That said, hyaluronic acid alone isn’t the best thing to use during sex. Water-based or silicone-based lubricants that don't contain glycerin will do a much better job of preventing friction and increasing pleasurable sensation during penetrative sex. A combination of vaginal hyaluronic acid (before and after sex) and lube (during sex) is the best option. 

Is hyaluronic acid better than vitamin E suppositories?

“Better” is subjective. Hyaluronic acid and vitamin E suppositories both support vaginal moisture and comfort, but they work a bit differently, and one may be a better fit depending on your specific needs. Hyaluronic acid is a powerful humectant, meaning it attracts and retains moisture. It hydrates the vaginal tissue and can help repair the mucosal lining, especially helpful for vaginal dryness due to menopause, postpartum recovery, or infection-related irritation. Vitamin E is an antioxidant that supports skin healing and reduces inflammation. It can soothe irritated tissue and improve elasticity, but it doesn’t hydrate as deeply or effectively as hyaluronic acid. Many people find that hyaluronic acid works more quickly and provides longer-lasting hydration, especially when dryness is severe. That said, the two can also complement each other, and some products even combine both. If you're unsure which is right for you, talk to your healthcare provider. For targeted, long-lasting dryness relief with minimal irritation, hyaluronic acid is often considered the more effective choice.

Is hyaluronic acid better than estrogen cream for vaginal dryness?

Hyaluronic acid and estrogen cream can both help relieve vaginal dryness, but they work in different ways, and which one is “better” depends on your body and the root cause of your dryness. Estrogen cream delivers a low dose of hormone directly to the vaginal tissues, helping to rebuild and thicken the vaginal lining. It’s especially effective for people with genitourinary syndrome of menopause or who have low estrogen levels due to menopause, breastfeeding, or certain medical treatments. Estrogen creams often provide fast, noticeable relief, but they may not be suitable for everyone, especially those who can’t or prefer not to use hormones. Hyaluronic acid, on the other hand, is a non-hormonal, deeply hydrating option that works by attracting moisture and helping the tissue repair itself. It’s great for people with mild to moderate dryness, sensitive tissue, or anyone looking for a gentle, hormone-free solution. For some, hyaluronic acid is enough on its own; for others, especially those with more severe symptoms or hormonal imbalances, estrogen cream may offer more complete relief.